Signal transduction by the TGF-β superfamily

被引：1082

作者：

Attisano, L

Wrana, JL

机构：

[1] Univ Toronto, Dept Anat & Cell Biol, Toronto, ON M5S 1A8, Canada

[2] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5S 1A8, Canada

[3] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Program Mol Biol & Canc, Toronto, ON M5G 1X5, Canada

来源：

SCIENCE | 2002年 / 296卷 / 5573期

关键词：

D O I：

10.1126/science.1071809

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Transforming growth factor-beta (TGF-beta) superfamily members regulate a plethora of developmental processes, and disruption of their activity has been implicated in a variety of human diseases ranging from cancer to chondrodysplasias and pulmonary hypertension. Intense investigations have revealed that SMAD proteins constitute the basic components of the core intracellular signaling cascade and that SMADs function by carrying signals from the cell surface directly to the nucleus. Recent insights have revealed how SMAD proteins themselves are regulated and how appropriate subcellular localization of SMADs and TGF-beta transmembrane receptors is controlled. Current research efforts investigating the contribution of SMAD-independent pathways promise to reveal advances to enhance our understanding of the signaling cascade.

引用

页码：1646 / 1647

页数：2

共 11 条

[1]

ATTISANO L, 2002, SCI STKE

[2]

ATTISANO L, 2001, GEN BIOL, V2

[3] Role of transforming growth factor-β signaling in cancer [J].