Tumor angiogenesis as a predictor of recurrence in stage Ib squamous cell carcinoma of the cervix

被引:48
作者
Dinh, TV [1 ]
Hannigan, EV [1 ]
Smith, ER [1 ]
Hove, MJ [1 ]
Chopra, V [1 ]
To, T [1 ]
机构
[1] UNIV TEXAS,MED BRANCH,DEPT PATHOL,GALVESTON,TX 77555
关键词
D O I
10.1016/0029-7844(96)00039-7
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To explore the possibility of using histologic microvessel count of sections from the tumor to predict recurrence of stage Ib squamous cell carcinoma of the cervix. Methods: Tumor sections from 22 patients (11 patients free of disease after 3 years and 11 patients with recurrence) were stained histoimmunochemically for factor VIII-related antigens. Vessel counting in the most active area of angiogenesis was performed by two pathologists on a x 200 microscopic field (0.739 mm(2)) without knowledge of the patients' outcome. To predict recurrence, vessel count was compared with age, tumor size, tumor grade, lymph-vascular invasion, duration of follow-up, and type of therapy. Results: Only high microvessel count (mean 19.9, range 7-43, versus mean 30.1, range 17-78; P < .05) and tumor size (mean 2.84 cm, range 1-4.2, versus mean 4.11 cm, range 2.2-6; P < .05) were independent factors predicting recurrence. Conclusion: High microvessel count in tumors may be used to predict recurrence in stage Ib squamous cell carcinoma of the cervix.
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收藏
页码:751 / 754
页数:4
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