Impaired antiviral response and alpha/beta interferon induction in mice lacking beta interferon

被引：143

作者：

Deonarain, R

Alcamí, A

Alexiou, M

Dallman, MJ

Gewert, DR

Porter, ACG

机构：

[1] Hammersmith Hosp, Imperial Coll, MRC,Clin Sci Ctr, Sch Med,Gene Targeting Grp, London W12 0NN, England

[2] Univ Cambridge, Dept Pathol, Div Virol, Cambridge CB2 1QP, England

[3] Univ London Imperial Coll Sci Technol & Med, Dept Biol, London SW7 2AZ, England

[4] QT Genet Ltd, Cambridge CB4 3GA, England

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.74.7.3404-3409.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have generated mice lacking the gene for beta interferon and report that they are highly susceptible to vaccinia virus infection. Furthermore, in cultured embryo fibroblasts, viral induction of alpha interferon and of 2-5A synthetase genes is impaired. We also show that beta interferon does not prime its own expression.

引用

收藏

页码：3404 / 3409

页数：6

相关论文

共 47 条

[1] THE HUMAN INTERFERON ALPHA-RECEPTOR PROTEIN CONFERS DIFFERENTIAL RESPONSES TO HUMAN INTERFERON-BETA VERSUS INTERFERON-ALPHA SUBTYPES IN MOUSE AND HAMSTER-CELL TRANSFECTANTS [J].

ABRAMOVICH, C ;

CHEBATH, J ;

REVEL, M .

CYTOKINE, 1994, 6 (04) :414-424

[2] A SOLUBLE RECEPTOR FOR INTERLEUKIN-1-BETA ENCODED BY VACCINIA VIRUS - A NOVEL MECHANISM OF VIRUS MODULATION OF THE HOST RESPONSE TO INFECTION [J].

ALCAMI, A ;

SMITH, GL .

CELL, 1992, 71 (01) :153-167

[3]

[Anonymous], 1994, MANIPULATING MOUSE E

[4] INDUCTION OF INTERFERON-ALPHA BY INTERFERON-BETA, BUT NOT OF INTERFERON-BETA BY INTERFERON-ALPHA, IN THE MOUSE [J].

ASANO, M ;

HAYASHI, M ;

YOSHIDA, E ;

KAWADE, Y ;

IWAKURA, Y .

VIROLOGY, 1990, 176 (01) :30-38

[5] MASS-PRODUCTION OF HUMAN INTERFERON IN DIPLOID CELLS STIMULATED BY POLY-I-C [J].

BILLIAU, A ;

JONIAU, M ;

DESOMER, P .

JOURNAL OF GENERAL VIROLOGY, 1973, 19 (APR) :1-8

[6] VACCINIA VIRUS B18R GENE ENCODES A TYPE-I INTERFERON-BINDING PROTEIN THAT BLOCKS INTERFERON-ALPHA TRANSMEMBRANE SIGNALING [J].

COLAMONICI, OR ;

DOMANSKI, P ;

SWEITZER, SM ;

LARNER, A ;

BULLER, RML .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (27) :15974-15978

[7] The human type I interferon receptor - Identification of the interferon beta-specific receptor-associated phosphoprotein [J].

Croze, E ;

RussellHarde, D ;

Wagner, TC ;

Pu, HF ;

Pfeffer, LM ;

Perez, HD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (52) :33165-33168

[8] JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS [J].

DARNELL, JE ;

KERR, IM ;

STARK, GR .

SCIENCE, 1994, 264 (5164) :1415-1421

[9] STATs and gene regulation [J].

Darnell, JE .

SCIENCE, 1997, 277 (5332) :1630-1635

[10]

DEONARAIN RK, 1999, THESIS U LONDON LOND

← 1 2 3 4 5 →