Differential distribution of BDNF and TRKB in regenerating dorsal column axons

被引：1

作者：

Cameron, AA ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT BIOL,LA JOLLA,CA 92093

来源：

NEUROREPORT | 1997年 / 8卷 / 12期

关键词：

neurotrophin; primary afferent; sciatic; spinal cord; transplantation;

D O I：

10.1097/00001756-199708180-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Dorsal column axons can regenerate into peripheral nerve grafts. The neurotrophin BDNF and its receptor TrkB are synthesized in dorsal root ganglion neurons, and have been implicated in regeneration. The aim of this study was to examine the distribution of BDNF and TrkB in dorsal column axons which regenerated into a peripheral nerve graft. BDNF-stained axons were found in all regions of the graft. BDNF was also expressed in small neurons in the superficial dorsal horn adjacent to the graft. TrkB was not found in any regenerating axons. Thus BDNF and TrkB are differentially expressed in regenerating dorsal column axons. In these axons BDNF may play a role that is independent of TrkB.

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页码：2655 / 2659

页数：5

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