A positive look at double-negative thymocytes

被引：155

作者：

Ceredig, R

Rolink, T

机构：

[1] CEA, U548 INSERM, F-38054 Grenoble, France

[2] Univ Basel, Pharmactr, Dept Immunol, CH-4065 Basel, Switzerland

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 11期

关键词：

D O I：

10.1038/nri937

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In some respects, our understanding of the cellular and molecular aspects of early T-cell differentiation is lagging behind that of B cells. Papers describing gene-knockout and reporter-transgenic mice in which thymocyte development is affected are often difficult to interpret. Progress in this field will be hampered unless a more detailed phenotypic and molecular analysis of progenitor thymocytes at the single-cell level is carried out.

引用

收藏

页码：888 / 896

页数：9

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