AN ENRICHED ENVIRONMENT RESTORES NORMAL BEHAVIOR WHILE PROVIDING CYTOSKELETAL RESTORATION AND SYNAPTIC CHANGES IN THE HIPPOCAMPUS OF RATS EXPOSED TO AN EXPERIMENTAL MODEL OF DEPRESSION

被引：38

作者：

Sifonios, L. ^{[1
]}

Trinchero, M. ^{[1
]}

Cereseto, M. ^{[1
]}

Ferrero, A. ^{[1
]}

Cladouchos, M. L. ^{[1
]}

Macedo, G. F. ^{[1
]}

Reines, A. ^{[1
,2
]}

Wikinski, S. ^{[1
,3
]}

机构：

[1] UBA, CONICET, ININFA, RA-1113 Buenos Aires, DF, Argentina

[2] UBA, Fac Farm & Bioquim, Catedra Farmacol, RA-1113 Buenos Aires, DF, Argentina

[3] UBA, Fac Med, Primera Catedra Farmacol, RA-1113 Buenos Aires, DF, Argentina

来源：

NEUROSCIENCE | 2009年 / 164卷 / 03期

关键词：

major depression; plasticity; cytoskeleton; synaptogenesis; stress; LEARNED HELPLESSNESS PARADIGM; NEUROTROPHIC FACTOR BDNF; DENTATE GYRUS; POSTSYNAPTIC DENSITY; SPATIAL MEMORY; NEURONAL DIFFERENTIATION; INCREASES NEUROGENESIS; CELL-PROLIFERATION; CHRONIC STRESS; MESSENGER-RNA;

D O I：

10.1016/j.neuroscience.2009.08.059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The exposure of rats to an enriched environment (EE) has several effects in common with the administration of antidepressants. However, there is still little information about the molecular underpinnings of these effects on rats subjected to experimental models of depression. The aim of this research was to evaluate the effects of EE on rats exposed to the learned helplessness paradigm (LH), a well-known model of the disease. We found that a 21 day exposure to EE reverts helplessness behavior to normal in LH animals. Inmunohistochemical labeling showed that this effect was accompanied by normalization of two structural proteins of hippocampal neurons to control values: the light neurofilament subunit (NFL) and the postsynaptic density 95 (PSD-95) protein, which were decreased in LH animals housed in standard cages. The decrease in the presynaptic protein synaptophysin (SYN) observed in LH animals remained unchanged after exposure to EE. There was no increase in neurogenesis as measured by quantification of double-labeled cells with 5-bromo-2'-deoxyuridine (BrdU) and the neuronal marker beta-tubulin class Ill. These results show that EE may have behavioral and synaptic effects on animals exposed to an experimental model of depression, and that such actions seem to be independent from neurogenesis. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：929 / 940

页数：12

共 67 条

[1]

[Anonymous], 2001, CURR PROTOC NEUROSCI, DOI [DOI 10.1002/0471142301.NS0810CS14, DOI 10.1002/0471142301.11S0810CSIL.]

[2] Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: Effects of pretreatment with saline or diazepam [J].

Bagley, J ;

Moghaddam, B .

NEUROSCIENCE, 1997, 77 (01) :65-73

[3] Long-term continuous, but not daily, environmental enrichment reduces spatial memory decline in aged male mice [J].

Bennett, JC ;

McRae, PA ;

Levy, LJ ;

Frick, KM .

NEUROBIOLOGY OF LEARNING AND MEMORY, 2006, 85 (02) :139-152

[4] Post insult enriched housing improves the 8-arm radial maze performance but not the Morris water maze task in ventral subicular lesioned rats [J].

Bindu, B ;

Rekha, J ;

Kutty, BM .

BRAIN RESEARCH, 2005, 1063 (02) :121-131

[5] Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis [J].

Brown, J ;

Cooper-Kuhn, CM ;

Kempermann, G ;

Van Praag, H ;

Winkler, J ;

Gage, FH ;

Kuhn, HG .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 17 (10) :2042-2046

[6] New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment [J].

Bruel-Jungerman, E ;

Laroche, S ;

Rampon, C .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (02) :513-521

[7] Impaired expression of postsynaptic density proteins in the hippocampal CA1 region of rats following perinatal hypoxia [J].

Chen, Wu-Fu ;

Chang, Hung ;

Wong, Chih-Shung ;

Huang, Li-Tung ;

Yang, Chin-Hwa ;

Yang, San-Nan .

EXPERIMENTAL NEUROLOGY, 2007, 204 (01) :400-410

[8] Social and structural housing conditions influence the development of a depressive-like phenotype in the learned helplessness paradigm in male mice [J].

Chourbaji, S ;

Zacher, C ;

Sanchis-Segura, C ;

Spanagel, R ;

Gass, P .

BEHAVIOURAL BRAIN RESEARCH, 2005, 164 (01) :100-106

[9] Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression [J].

Colledge, M ;

Snyder, EM ;

Crozier, RA ;

Soderling, JA ;

Jin, YT ;

Langeberg, LK ;

Lu, H ;

Bear, MF ;

Scott, JD .

NEURON, 2003, 40 (03) :595-607

[10] Enriched environment experience overcomes the memory deficits and depressive-like behavior induced by early life stress [J].

Cui, Minghu ;

Yang, Ya ;

Yang, Jianli ;

Zhang, Jichuan ;

Han, Huili ;

Ma, Wenpei ;

Li, Hongbin ;

Mao, Rongrong ;

Xu, Lin ;

Hao, Wei ;

Cao, Jun .

NEUROSCIENCE LETTERS, 2006, 404 (1-2) :208-212

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