共 33 条
Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs
被引:80
作者:

Eto, Y
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机构: Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan

Shimokawa, H
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机构: Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan

Hiroki, J
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机构: Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan

Morishige, K
论文数: 0 引用数: 0
h-index: 0
机构: Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan

Kandabashi, T
论文数: 0 引用数: 0
h-index: 0
机构: Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan

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Hoshijima, M
论文数: 0 引用数: 0
h-index: 0
机构: Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan

Kaibuchi, K
论文数: 0 引用数: 0
h-index: 0
机构: Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan

Takeshita, A
论文数: 0 引用数: 0
h-index: 0
机构: Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan
机构:
[1] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan
[2] Nara Inst Sci & Technol, Div Signal Transduct, Nara 6300121, Japan
[3] Univ Calif San Diego, La Jolla, CA 92093 USA
来源:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
|
2000年
/
278卷
/
06期
关键词:
restenosis;
signal transduction;
small guanosine 5 '-triphosphate-binding protein;
vascular smooth muscle;
D O I:
10.1152/ajpheart.2000.278.6.H1744
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Restenosis after angioplasty still remains a major problem for which neointimal formation appears to play an important role. Recent studies in vitro suggested that Rho kinase, a target protein of Rho, is important in various cellular functions. We thus examined whether Rho kinase is involved in the restenotic changes after balloon injury. In vivo gene transfer was performed immediately after balloon injury in both sides of the porcine femoral arteries with adenoviral vector encoding either a dominant negative form of Rho kinase (AdDNRhoK) or beta-galactosidase (AdLacZ) as a control. One week after the transfer, immunohistochemistry confirmed the successful gene expression in the vessel wall, whereas 2 wk after the transfer, Western blotting showed the functional upregulation of Rho kinase at the AdLacZ site and its suppression at the AdDNRhoK site. Angiography showed the development of a stenotic lesion at the AdLacZ site where histological neointimal formation was noted, whereas those changes were significantly suppressed at the AdDNRhoK site. These results indicate that Rho kinase is involved in the pathogenesis of neointimal formation after balloon injury in vivo.
引用
收藏
页码:H1744 / H1750
页数:7
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