Overexpression of Agrt leads to obesity in transgenic mice

被引:310
作者
Graham, M
Shutter, JR
Sarmiento, U
Sarosi, I
Stark, KL
机构
[1] AMGEN INC,DEPT MOL GENET,THOUSAND OAKS,CA 91320
[2] AMGEN INC,DEPT PATHOL,THOUSAND OAKS,CA 91320
关键词
D O I
10.1038/ng1197-273
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页码:273 / 274
页数:2
相关论文
共 12 条
[1]   MOLECULAR CHARACTERIZATION OF THE MOUSE AGOUTI LOCUS [J].
BULTMAN, SJ ;
MICHAUD, EJ ;
WOYCHIK, RP .
CELL, 1992, 71 (07) :1195-1204
[2]   Role of melanocortinergic neurons in feeding and the agouti obesity syndrome [J].
Fan, W ;
Boston, BA ;
Kesterson, RA ;
Hruby, VJ ;
Cone, RD .
NATURE, 1997, 385 (6612) :165-168
[3]   ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors [J].
Fong, TM ;
Mao, C ;
MacNeil, T ;
Kalyani, R ;
Smith, T ;
Weinberg, D ;
Tota, MR ;
VanderPloeg, LHT .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 237 (03) :629-631
[4]   Obesity - The alphabet of weight control [J].
Friedman, JM .
NATURE, 1997, 385 (6612) :119-120
[5]  
HESTON WE, 1962, J NATL CANCER I, V29, P197
[6]  
Hogan B., 1986, MANIPULATING MOUSE E
[7]   Targeted disruption of the melanocortin-4 receptor results in obesity in mice [J].
Huszar, D ;
Lynch, CA ;
FairchildHuntress, V ;
Dunmore, JH ;
Fang, Q ;
Berkemeier, LR ;
Gu, W ;
Kesterson, RA ;
Boston, BA ;
Cone, RD ;
Smith, FJ ;
Campfield, LA ;
Burn, P ;
Lee, F .
CELL, 1997, 88 (01) :131-141
[8]   ECTOPIC EXPRESSION OF THE AGOUTI GENE IN TRANSGENIC MICE CAUSES OBESITY, FEATURES OF TYPE-II DIABETES, AND YELLOW FUR [J].
KLEBIG, ML ;
WILKINSON, JE ;
GEISLER, JG ;
WOYCHIK, RP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (11) :4728-4732
[9]   AGOUTI PROTEIN IS AN ANTAGONIST OF THE MELANOCYTE-STIMULATING-HORMONE RECEPTOR [J].
LU, DS ;
WILLARD, D ;
PATEL, IR ;
KADWELL, S ;
OVERTON, L ;
KOST, T ;
LUTHER, M ;
CHEN, WB ;
WOYCHIK, RP ;
WILKISON, WO ;
CONE, RD .
NATURE, 1994, 371 (6500) :799-802
[10]   ECTOPIC EXPRESSION OF A C-KITW42 MINIGENE IN TRANSGENIC MICE - RECAPITULATION OF W-PHENOTYPES AND EVIDENCE FOR C-KIT FUNCTION IN MELANOBLAST PROGENITORS [J].
RAY, P ;
HIGGINS, KM ;
TAN, JC ;
CHU, TY ;
YEE, NS ;
NGUYEN, H ;
LACY, E ;
BESMER, P .
GENES & DEVELOPMENT, 1991, 5 (12A) :2265-2273