The development of androgen-independent prostate cancer

被引：1902

作者：

Feldman, BJ ^{[1
]}

Feldman, D ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Div Endocrinol, Dept Med, Stanford, CA 94305 USA

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 01期

关键词：

D O I：

10.1038/35094009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress. Cancers that are not cured by surgery eventually become androgen independent, rendering anti-androgen therapy ineffective. But how does androgen independence arise? We predict that understanding the pathways that lead to the development of androgen-independent prostate cancer will pave the way to effective therapies for these, at present, untreatable cancers.

引用

页码：34 / 45

页数：12

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