IL-15Rα recycles and presents IL-15 in trans to neighboring cells

被引：752

作者：

Dubois, S ^{[1
]}

Mariner, J ^{[1
]}

Waldmann, TA ^{[1
]}

Tagaya, Y ^{[1
]}

机构：

[1] NCI, Metab Branch, Canc Res Ctr, NIH, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2002年 / 17卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(02)00429-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report intriguing aspects of the contribution of IL-15Ralpha to IL-15 functions. Consistent with high-affinity interactions between IL-15 and IL-1513, these two molecules form stable complexes on the cell surface of activated monocytes. The formation of IL-15/IL-15Ralpha complexes on cell surfaces induces a transendosomal recycling of IL-15 leading to the persistence of surface-bound IL-15 due to the constant reappearance of IL-15 on plasma membranes. This complex contributes to the long survival of T cells expressing IL-15Ra after IL-15 withdrawal. Finally, these complexes on activated monocytes present IL-15 in trans to target cells such as CD8+ T cells that express only IL-2/15Rbeta and gammac upon cell-cell interaction.

引用

页码：537 / 547

页数：11

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