共 41 条
Generation of insulin-producing cells from PDX-1 gene-modified human mesenchymal stem cells
被引:118
作者:

Li, Yanhua
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机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China

Zhang, Rui
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机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China

Qiao, Haifa
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h-index: 0
机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China

Zhang, Heping
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h-index: 0
机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China

Wang, Yunfang
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h-index: 0
机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China

Yuan, Hongfeng
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机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China

Liu, Qinbin
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机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China

Liu, Daqing
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机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China

Chen, Lin
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机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China

Pei, Xuetao
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机构: Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China
机构:
[1] Beijing Inst Transfus Med, Dept Stem Cells & Regenerat Med, Beijing 100850, Peoples R China
[2] Beijing Inst Pharmacol & Toxicol, Dept Neuropharmacol, Beijing, Peoples R China
关键词:
D O I:
10.1002/jcp.20897
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Islet cell replacement is considered as the optimal treatment for type I diabetes. However, the availability of human pancreatic islets for transplantation is limited. Here, we show that human bone marrow-derived mesenchymal stem cells (hMSCs) could be induced to differentiate into functional insulin-producing cells by introduction of the pancreatic duodenal homeobox-1 (PDX-1). Recombinant adenoviral vector was used to deliver PDX-1 gene into hMSCs. After being infected with Ad-PDX-1, hMSCs were successfully induced to differentiate into insulin-secreting cells. The differentiated PDX-1(+) hMSCs expressed multiple islet-cell genes including neurogenin3 (Ngn3), insulin, GK, Glut2, and glucagon, produced and released insulin/C-peptide in a weak glucose-regulated manner. After the differentiated PDX-1 hMSCs were transplanted into STZ-induced diabetic mice, euglycemia can be obtained within 2 weeks and maintained for at least 42 days. These findings validate the hMSCs model system as a potential basis for enrichment of human beta cells or their precursors, and a possible source for cell replacement therapy in diabetes.
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页码:36 / 44
页数:9
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