Mitotic repression of the transcriptional machinery

被引:327
作者
Gottesfeld, JM [1 ]
Forbes, DJ [1 ]
机构
[1] UNIV CALIF SAN DIEGO, DEPT BIOL 0347, LA JOLLA, CA 92093 USA
关键词
D O I
10.1016/S0968-0004(97)01045-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nuclear RNA transcription is silenced when eukaryotic cells enter mitosis. Until recently, this repression was thought to derive solely from the condensation of interphase chromatin into mitotic chromosomes, Recent studies, however, haw: shown that changes in chromatin structure and occupancy of promoter elements by both general and gene-specific transcription factors also play a role in transcriptional silencing. In addition, studies with simplified systems reveal that reversible phosphorylation of the basal transcriptional machinery represses transcription at mitosis.
引用
收藏
页码:197 / 202
页数:6
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