Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome

被引：121

作者：

Vecchiet, J

Cipollone, F

Falasca, K

Mezzetti, A

Pizzigallo, E

Bucciarelli, T

De Laurentis, S

Affaitati, G

De Cesare, D

Giamberardino, MA ^{[1
]}

机构：

[1] Univ G DAnnunzio, Dept Med & Sci Aging, Chieti, Italy

[2] Univ G DAnnunzio, Dept Biochem Sci, Chieti, Italy

来源：

NEUROSCIENCE LETTERS | 2003年 / 335卷 / 03期

关键词：

oxidative stress; chronic fatigue syndrome; vitamin E; Lag Phase; thiobarbituric acid reactive substances; muscle pain thresholds;

D O I：

10.1016/S0304-3940(02)01058-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In 21 patients with chronic fatigue syndrome (CFS) versus 20 normal subjects, we investigated the oxidant/antioxidant balance and its correlation with muscle symptoms. Patients versus controls showed significantly: lower Lag Phase and Vitamin E (Vit E) concentrations in plasma and low-density lipoproteins (LDL), higher LDL thiobarbituric acid reactive substances (TBARS), higher fatigue and lower muscle pain thresholds to electrical stimulation. A significant direct linear correlation was found between fatigue and TBARS, thresholds and Lag Phase, thresholds and Vit E in plasma and LDL. A significant inverse linear correlation was found between fatigue and Lag Phase, fatigue and Vit E, thresholds and TBARS. Increased oxidative stress and decreased antioxidant defenses are related to the extent of symptomatology in CFS, suggesting that antioxidant supplementation might relieve muscle symptoms in the syndrome. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：151 / 154

页数：4

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