Cell replacement therapies for central nervous system disorders

被引：718

作者：

Björklund, A ^{[1
]}

Lindvall, O ^{[1
]}

机构：

[1] Univ Lund, Wallenberg Neurosci Ctr, S-22362 Lund, Sweden

来源：

NATURE NEUROSCIENCE | 2000年 / 3卷 / 06期

关键词：

D O I：

10.1038/75705

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In animal models, immature neural precursors can replace lest neurons, restore function and promote brain self-repair Clinical trials in Parkinson's disease suggest that similar approaches may also work in the diseased human brain. But how realistic is it that cell replacement can he developed into effective clinical therapy?

引用

页码：537 / 544

页数：8

共 63 条

[1] THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].

ALBIN, RL ;

YOUNG, AB ;

PENNEY, JB .

TRENDS IN NEUROSCIENCES, 1989, 12 (10) :366-375

[2]

ANNETT LE, 1994, FUNCTIONAL NEURAL TR, P71

[3] Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's disease [J].

Bachoud-Lévi, AC ;

Bourdet, C ;

Brugières, P ;

Nguyen, JP ;

Grandmougin, T ;

Haddad, B ;

Jény, R ;

Bartolomeo, P ;

Boissé, MF ;

Dalla Barba, G ;

Degos, JD ;

Ergis, AM ;

Lefaucheur, JP ;

Lisovoski, F ;

Pailhous, E ;

Rémy, P ;

Palfi, S ;

Defer, GL ;

Cesaro, P ;

Hantraye, P ;

Peschanski, M .

EXPERIMENTAL NEUROLOGY, 2000, 161 (01) :194-202

[4]

Bjorklund A, 1992, Curr Opin Neurobiol, V2, P683, DOI 10.1016/0959-4388(92)90039-N

[5]

Bjorklund A., 1994, FUNCTIONAL NEURAL TR, P157

[6] Transplantation of cryopreserved human embryonal carcinoma-derived neurons (NT2N cells) promotes functional recovery in ischemic rats [J].

Borlongan, CV ;

Tajima, Y ;

Trojanowski, JQ ;

Lee, VMY ;

Sanberg, PR .

EXPERIMENTAL NEUROLOGY, 1998, 149 (02) :310-321

[7] Cerebral ischemia and CNS transplantation: differential effects of grafted fetal rat striatal cells and human neurons derived from a clonal cell line [J].

Borlongan, CV ;

Tajima, Y ;

Trojanowski, J ;

Lee, VMY ;

Sanberg, PR .

NEUROREPORT, 1998, 9 (16) :3703-3709

[8] Associative plasticity in striatal transplants [J].

Brasted, PJ ;

Watts, C ;

Robbins, TW ;

Dunnett, SB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (18) :10524-10529

[9]

Brundin P., 1994, FUNCTIONAL NEURAL TR, P9

[10] Fetal raphe transplants reduce seizure severity in serotonin-depleted GEPRs [J].

Clough, R ;

Statnick, M ;

MaringSmith, M ;

Wang, CD ;

Eells, J ;

Browning, R ;

Dailey, J ;

Jobe, P .

NEUROREPORT, 1996, 8 (01) :341-346

← 1 2 3 4 5 6 7 →