Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190562 genetic variations in the human genome

被引：253

作者：

Haga, H ^{[1
]}

Yamada, R ^{[1
]}

Ohnishi, Y ^{[1
]}

Nakamura, Y ^{[1
]}

Tanaka, T ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Mol Med Lab, Ctr Human Genome,Minato Ku, Tokyo 1088639, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2002年 / 47卷 / 11期

关键词：

single-nucleotide polymorphism (SNP); Japanese population; genetic marker; association study; common diseases;

D O I：

10.1007/s100380200092

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To construct an infrastructure for genome-wide association studies of common diseases or drug sensitivities, we have been systematically exploring common variants by resequencing genomic regions containing genes in DNA from 24 Japanese individuals. We have analyzed a total of 154Mb, corresponding to approximately 5% of the human genome, and so far have identified 174269 single-nucleotide polymorphisms and 16293 insertion/deletion polymorphisms within gene regions, i.e., one polymorphism in 807 bp on average. Our data are freely available via our web site (http://snp.ims.u-tokyo.ac.jp) and will facilitate studies to identify genes associated with susceptibility to common diseases and genes involved in sensitivity to therapeutic drugs.

引用

页码：605 / 610

页数：6

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