How nucleotide excision repair protects against cancer

被引:582
作者
Friedberg, EC [1 ]
机构
[1] Univ Texas, SW Med Ctr, Dept Pathol, Lab Mol Pathol, Dallas, TX 75390 USA
关键词
D O I
10.1038/35094000
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Eukaryotic cells can repair many types of DNA damage. Among the known DNA repair processes in humans, one type - nucleotide excision repair (NER) - specifically protects against mutations caused indirectly by environmental carcinogens. Humans with a hereditary defect in NER suffer from xeroderma pigmentosum and have a marked predisposition to skin cancer caused by sunlight exposure. How does NER protect against skin cancer and possibly other types of environmentally induced cancer in humans?.
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页码:22 / 33
页数:12
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