Coping with replication 'train wrecks' in Escherichia coli using Pol V, Pol II and RecA proteins

被引:79
作者
Goodman, MF [1 ]
机构
[1] Univ So Calif, Dept Chem & Biol Sci, Los Angeles, CA 90089 USA
关键词
D O I
10.1016/S0968-0004(00)01564-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
DNA replication machineries tend to stall when confronted with damaged DNA template sites, causing the biochemical equivalent of a major 'train wreck'. A newly discovered bacterial DNA polymerase, Escherichia coli Pol V, acting in conjunction with the RecA protein, can exchange places with the stalled replicative Pol III core and catalyse 'error-prone' translesion synthesis. In contrast to Pol V-catalysed 'brute-force, sloppier copying', another SOS-induced DNA polymerase, Pol II, plays a pivotal role in an 'error-free', replication-restart DNA repair pathway and probably involves RecA-mediated homologous recombination.
引用
收藏
页码:189 / 195
页数:7
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