A blast from the past: Clearance of apoptotic cells regulates immune responses

被引：1276

作者：

Savill, J

Dransfield, I

Gregory, C

Haslett, C

机构：

[1] Univ Edinburgh, Royal Infirm, MRC, Ctr Inflammat Res,Dept Clin & Surg Sci Internal M, Edinburgh EH3 9YW, Midlothian, Scotland

[2] Univ Edinburgh, Royal Infirm, MRC, Ctr Inflammat Res,Dept Med & Radiol Sci Resp Med, Edinburgh EH3 9YW, Midlothian, Scotland

来源：

NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 12期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1038/nri957

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future.

引用

页码：965 / 975

页数：11

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