Stabilization of atherosclerotic plaques: New mechanisms and clinical targets

被引：431

作者：

Libby, P ^{[1
]}

Aikawa, M ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med,Dept Med, Cardiovasc Div,Leducq Ctr Cardiovasc Res, Boston, MA 02115 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nm1102-1257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research points to pivotal roles for lipids in the development of atherosclerotic plaques. Lipid-lowering statins substantially reduce acute coronary events resulting from plaque development, but only modestly reduce arterial stenosis. This apparent paradox has shifted the goal of therapy toward plaque stabilization rather than enlargement of the lumen. More thorough understanding to the biology of atherosclerosis should enable us to manipulate plaque stability, and reduce further the acute complications of atherosclerosis.

引用

页码：1257 / 1262

页数：6

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