Inhibition of ICE slows ALS in mice

被引：289

作者：

Friedlander, RM

Brown, RH

Gagliardini, V

Wang, J

Yuan, JY

机构：

[1] MASSACHUSETTS GEN HOSP,DAY NEUROMUSCULAR RES LAB,CHARLESTOWN,MA 02129

[2] HARVARD UNIV,SCH MED,MASSACHUSETTS GEN HOSP,CARDIOVASC RES CTR,DEPT MED,CHARLESTOWN,MA 02129

来源：

NATURE | 1997年 / 388卷 / 6637期

关键词：

D O I：

10.1038/40299

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Amyotrophic lateral sclerosis (ALS) is a progressive age-dependent disease involving degeneration of motor neurons in the brain, brainstem and spinal cord. ALS is universally fatal, with the median survival of patients being five years from diagnosis. In a transgenic mouse model of ALS, we now show that a dominant negative inhibitor of a cell-death gene, the interleukin-1β-converting enzyme (ICE), significantly slows the symptomatic progression of ALS.

引用

页码：31 / 31

页数：1

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