Polyglutamine expansions: Proteolysis, chaperones, and the dangers of promiscuity

被引：53

作者：

Ferrigno, P

Silver, PA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Canc Biol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

NEURON | 2000年 / 26卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(00)81132-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

[No abstract available]

引用

页码：9 / 12

页数：4

共 19 条

[1] A HOMOLOG OF THE BACTERIAL HEAT-SHOCK GENE DNAJ THAT ALTERS PROTEIN SORTING IN YEAST [J].

BLUMBERG, H ;

SILVER, PA .

NATURE, 1991, 349 (6310) :627-630

[2]

Chai YH, 1999, J NEUROSCI, V19, P10338

[3] Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice [J].

Cummings, CJ ;

Reinstein, E ;

Sun, YL ;

Antalffy, B ;

Jiang, YH ;

Ciechanover, A ;

Orr, HT ;

Beaudet, AL ;

Zoghbi, HY .

NEURON, 1999, 24 (04) :879-892

[4] Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation [J].

Davies, SW ;

Turmaine, M ;

Cozens, BA ;

DiFiglia, M ;

Sharp, AH ;

Ross, CA ;

Scherzinger, E ;

Wanker, EE ;

Mangiarini, L ;

Bates, GP .

CELL, 1997, 90 (03) :537-548

[5] Regulation of expanded polyglutamine protein aggregation and nuclear localization by the glucocorticoid receptor [J].

Diamond, MI ;

Robinson, MR ;

Yamamoto, KR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (02) :657-661

[6] CHARACTERIZATION AND LOCALIZATION OF THE HUNTINGTON DISEASE GENE-PRODUCT [J].

HOOGEVEEN, AT ;

WILLEMSEN, R ;

MEYER, N ;

DEROOIJ, KE ;

ROOS, RAC ;

VANOMMEN, GJB ;

GALJAARD, H .

HUMAN MOLECULAR GENETICS, 1993, 2 (12) :2069-2073

[7] Genetic suppression of polyglutamine toxicity in Drosophila [J].

Kazemi-Esfarjani, P ;

Benzer, S .

SCIENCE, 2000, 287 (5459) :1837-1840

[8] Ataxin-1 nuclear localization and aggregation:: Role in polyglutamine-induced disease in SCA1 transgenic mice [J].

Klement, IA ;

Skinner, PJ ;

Kaytor, MD ;

Yi, H ;

Hersch, SM ;

Clark, HB ;

Zoghbi, HY ;

Orr, HT .

CELL, 1998, 95 (01) :41-53

[9] Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins [J].

Krobitsch, S ;

Lindquist, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (04) :1589-1594

[10]

Li SH, 1999, J NEUROSCI, V19, P5159

← 1 2 →