Clinical significance of the antibody against oxidized low-density lipoprotein in acute myocardial infarction

被引：14

作者：

Inoue, T ^{[1
]}

Yaguchi, I ^{[1
]}

Uchida, T ^{[1
]}

Kamishirado, H ^{[1
]}

Nakahara, S ^{[1
]}

Hayashi, T ^{[1
]}

Morooka, S ^{[1
]}

机构：

[1] Dokkyo Univ, Sch Med, Koshigaya Hosp, Dept Cardiol, Koshigaya, Saitama 3438555, Japan

来源：

CARDIOLOGY | 2002年 / 98卷 / 1-2期

关键词：

acute myocardial infarction; antibody; oxidized low-density lipoprotein; plaque instability;

D O I：

10.1159/000064672

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To establish the clinical significance of the antibody against oxidized low-density lipoprotein (anti-Ox-LDL) titer in patients with acute myocardial infarction (AMI), we measured the anti-Ox-LDL titer in 39 patients with AMI and 25 controls. in all AMI patients, the anti-Ox-LDL titer on admission was higher (p < 0.05) than the value in the controls. One month after admission, the titer decreased significantly (p < 0.001) reaching control levels. In patients who underwent thrombolytic therapy, the anti-Ox-LDL titer on admission was identical in patients with occluded infarct-related arteries (IRA) and patients with patent IRA during emergency coronary angiography, In patients who did not undergo thrombolytic therapy, the anti-Ox-LDL titer on admission was higher in patients with occluded IRA than in patients with patent IRA. An increased anti-Ox-LDL titer may be a risk factor for the onset of AMI. Spontaneous recanalization of the IRA may be associated with increased anti-Ox-LDL titers, while thrombolysis-induced recanalization may be independent of it. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：13 / 17

页数：5

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