Family History and APOE-4 Genetic Risk in Alzheimer's Disease

被引：50

作者：

Donix, Markus ^{[1
,2
]}

Small, Gary W. ^{[4
,6
]}

Bookheimer, Susan Y. ^{[3
,4
,5
]}

机构：

[1] Tech Univ Dresden, Dept Psychiat & Psychotherapy, Univ Klinikum Carl Gustav Carus, D-01307 Dresden, Germany

[2] German Ctr Neurodegenerat Dis, DZNE, Dresden, Germany

[3] Univ Calif Los Angeles, David Geffen Sch Med, Ctr Cognit Neurosci, Semel Inst, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Semel Inst, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychol, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, Longev Ctr, Los Angeles, CA 90095 USA

来源：

NEUROPSYCHOLOGY REVIEW | 2012年 / 22卷 / 03期

关键词：

Alzheimer's disease; APOE Genotype; Family history; Genetic risk; Risk factors; Neuroimaging; WHITE-MATTER INTEGRITY; POSITRON-EMISSION-TOMOGRAPHY; GENOME-WIDE ASSOCIATION; AMYLOID-BETA BURDEN; APOLIPOPROTEIN-E; EPSILON-4; ALLELE; NORMAL INDIVIDUALS; COGNITIVE DECLINE; MATERNAL HISTORY; BRAIN ACTIVITY;

D O I：

10.1007/s11065-012-9193-2

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Identifying risk factors for Alzheimer's disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer's disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.

引用

页码：298 / 309

页数：12

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