Decreased plasma adiponectin concentration in patients with essential hypertension

被引：366

作者：

Adamczak, M

Wiecek, A ^{[1
]}

Funahashi, T

Chudek, J

Kokot, F

Matsuzawa, Y

机构：

[1] Silesian Univ Sch Med, Dept Nephrol Endocrinol & Metab Dis, PL-40027 Katowice, Poland

[2] Osaka Univ, Dept Internal Med & Mol Med, Osaka, Japan

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2003年 / 16卷 / 01期

关键词：

essential hypertension; adiponectin; adipose tissue; leptin;

D O I：

10.1016/S0895-7061(02)03197-7

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Adipocytes secrete several biologically active substances that are presumed to be involved in obesity-related hypertension. There are no reports that deal with the relationship between plasma adiponectin concentration and blood pressure (BP). To evaluate the role of adiponectin in essential hypertension 33 patients with essential hypertensive (EHP) (12 women, 21 men) and 33 body mass index-matched normotensive healthy subjects (NHS) (13 women, 20 men) were studied. In EHP plasma adiponectin concentration was significantly lower than in NHS (9.1 +/- 4.5 v 13.7 +/- 5.2 mug/mL, respectively). In all subjects a significant negative correlation was found between plasma adiponectin concentration and mean, systolic, and diastolic BP, suggesting that adiponectin contributes to the clinical course of essential hypertension.

引用

页码：72 / 75

页数：4

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