EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family

被引：39

作者：

Callebaut, I

Cossart, P

Dehoux, P ^{[1
]}

机构：

[1] Univ Paris 06, LMCP, CNRS, UMRC 7590, Paris, France

[2] Univ Paris 07, LMCP, CNRS, UMRC 7590, Paris, France

[3] Inst Pasteur, Unite Interact Bacteries Cellules, F-75010 Paris, France

来源：

FEBS LETTERS | 1998年 / 441卷 / 02期

基金：

澳大利亚研究理事会;

关键词：

sequence analysis; polyproline; WH1; domain; EVH1;

D O I：

10.1016/S0014-5793(98)01541-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The two cytoskeletal proteins VASP and WASP and the protein Homer share a conserved domain, currently designated the WH1 domain (WASP homology domain I) or EVH1 domain (ENA/VASP homology domain 1), which could play an important role in various cellular events such as transport, folding of proteins, and signal transduction. We report here additional occurrences of this domain in Ran-binding proteins of the RanBP1 family and various others proteins, or putative proteins of eukaryotic organisms, suggesting that the EVH1/WH1 domain may be more widely used than originally thought. (C) 1998 Federation of European Biochemical Societies.

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收藏

页码：181 / 185

页数：5

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