Dopaminergic neurons protected from degeneration by GDNF gene therapy

被引：535

作者：

ChoiLundberg, DL

Lin, Q

Chang, YN

Chiang, YL

Hay, CM

Mohajeri, H

Davidson, BL

Bohn, MC

机构：

[1] UNIV ROCHESTER,DEPT NEUROBIOL & ANAT,ROCHESTER,NY 14642

[2] GENET THERAPY,GAITHERSBURG,MD 20878

[3] UNIV IOWA,COLL MED,DEPT INTERNAL MED,IOWA CITY,IA 52242

来源：

SCIENCE | 1997年 / 275卷 / 5301期

关键词：

D O I：

10.1126/science.275.5301.838

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Glial cell line-derived neurotrophic factor (GDNF) supports growth and survival of dopaminergic (DA) neurons. A replication-defective adenoviral (Ad) vector encoding human GDNF injected near the rat substantia nigra was found to protect DA neurons from the progressive degeneration induced by the neurotoxin 6-hydroxydopamine (6-OHDA) injected into the striatum, Ad GDNF gene therapy reduced loss of DA neurons approximately threefold 6 weeks after 6-OHDA lesion, as compared with no treatment or injection of Ad lacZ or Ad mGDNF (encoding a biologically inactive deletion mutant GDNF). These results suggest that Ad vector-mediated GDNF gene therapy may slow the DA neuronal cell loss in humans with Parkinson's disease.

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页码：838 / 841

页数：4

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