JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex

被引：117

作者：

Jin, Y ^{[1
]}

Wang, YM ^{[1
]}

Johansen, J ^{[1
]}

Johansen, KM ^{[1
]}

机构：

[1] Iowa State Univ Sci & Technol, Dept Zool & Genet, Ames, IA 50011 USA

来源：

JOURNAL OF CELL BIOLOGY | 2000年 / 149卷 / 05期

关键词：

protein kinase; dosage compensation; Drosophila; chromatin; MSL complex;

D O I：

10.1083/jcb.149.5.1005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL-1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.

引用

页码：1005 / 1010

页数：6

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