Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

被引：3921

作者：

Calin, GA

Dumitru, CD

Shimizu, M

Bichi, R

Zupo, S

Noch, E

Aldler, H

Rattan, S

Keating, M

Rai, K

Rassenti, L

Kipps, T

Negrini, M

Bullrich, F

Croce, CM

机构：

[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA

[2] Univ Calif San Diego, Dept Med, La Jolla, CA 92093 USA

[3] Long Isl Jewish Med Ctr, New Hyde Pk, NY 11042 USA

[4] Univ Texas, MD Anderson Canc Ctr, Dept Leukemia, Houston, TX 77030 USA

[5] Natl Inst Canc Res, I-16132 Genoa, Italy

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 24期

关键词：

D O I：

10.1073/pnas.242606799

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Micro-RNAs (miR genes) are a large family of highly conserved noncoding genes thought to be involved in temporal and tissue-specific gene regulation. MiRs are transcribed as short hairpin precursors (approximate to70 nt) and are processed into active 21- to 22-nt RNAs by Dicer, a ribonuclease that recognizes target mRNAs via base-pairing interactions. Here we show that miR15 and miR16 are located at chromosome 13q14, a region deleted in more than half of B cell chronic lymphocytic leukemias (B-CLL). Detailed deletion and expression analysis shows that miR15 and miR16 are located within a 30-kb region of loss in CLL, and that both genes are deleted or down-regulated in the majority (approximate to68%) of CLL cases.

引用

页码：15524 / 15529

页数：6

共 39 条

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