Flavonoids, triterpenoids and a lignan from Vitex altissima

被引：38

作者：

Sridhar, C

Rao, KV

Subbaraju, GV ^{[1
]}

机构：

[1] Laila Impex R&D Ctr, Vijayawada 520007, India

[2] Sri Padmavathi Sch Pharm, Dept Pharmaceut Chem, Tirupati 517503, Andhra Pradesh, India

[3] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, Mississippi State, MS USA

来源：

PHYTOCHEMISTRY | 2005年 / 66卷 / 14期

关键词：

Vitex altissima; leaves; lignan; altissinone; flavonoids; triterpenoids; anti-inflammatory;

D O I：

10.1016/j.phytochem.2005.05.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new tetrahydrofuranoid lignan, altissinone (1) and a new acylated flavone C-glucoside, 2"-O-p-hydroxybenzoylorientin (2), were isolated in addition to several known triterpene acids and flavonoids from the ethyl acetate extractives of the leaves of Vitex altissima. The structures of the compounds were established based on interpretation of high resolution NMR (HMQC, HMBC and NOESY) spectral data. The ethyl acetate extract exhibited significant anti-inflammatory activity in rat paw edema model. The flavonoids and triterpene acids showed moderate antioxidant and 5-lipoxygenase enzyme inhibitory activities, respectively. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1707 / 1712

页数：6

共 30 条

[1] Acylated flavone C-glycosides from Cucumis sativus [J].