Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection

被引：34

作者：

Bowen, David G. ^{[1
]}

Shoukry, Naglaa H. ^{[2
,3
]}

Grakoui, Arash ^{[4
]}

Fuller, Michael J. ^{[1
]}

Cawthon, Andrew G. ^{[1
]}

Dong, Christine ^{[9
]}

Hasselschwert, Dana L. ^{[5
]}

Brasky, Kathleen M. ^{[6
]}

Freeman, Gordon J. ^{[7
]}

Seth, Nilufer P. ^{[8
]}

Wucherpfernnig, Kai W. ^{[8
]}

Houghton, Michael ^{[9
]}

Walker, Christopher M. ^{[1
,10
]}

机构：

[1] Nationwide Childrens Hosp, Res Inst, Ctr Vaccines & Immun, Columbus, OH 43205 USA

[2] Univ Montreal, Dept Med, Montreal, PQ H3C 3J7, Canada

[3] Univ Montreal Hosp Ctr, Montreal, PQ, Canada

[4] Emory Univ, Atlanta, GA 30322 USA

[5] New Iberia Res Ctr, New Iberia, LA USA

[6] SW Fdn Biomed Res, San Antonio, TX 78284 USA

[7] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[9] Novartis Corp, Emeryville, CA USA

[10] Ohio State Univ, Coll Med & Publ Hlth, Columbus, OH 43210 USA

来源：

JOURNAL OF VIROLOGY | 2008年 / 82卷 / 10期

关键词：

D O I：

10.1128/JVI.00060-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The inhibitory receptor programmed death-1 (PD-1) is present on CD8(+) T cells in chronic hepatitis C virus (HCV), but expression patterns in spontaneously resolving infections are incompletely characterized. Here we report that PD-1 was usually absent on memory CD8(+) T cells from chimpanzees with resolved infections, but sustained low-level expression was sometimes observed in the absence of apparent virus replication. PD-1-positive memory T cells expanded and displayed antiviral activity upon reinfection with HCV, indicating conserved function. This animal model should facilitate studies of whether PD-1 differentially influences effector and memory T-cell function in resolved versus persistent human infections.

引用

页码：5109 / 5114

页数：6

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