Cytotoxic activities and structure-cytotoxic relationships of steroidal saponins

被引：113

作者：

Mimaki, Y ^{[1
]}

Yokosuka, A ^{[1
]}

Kuroda, M ^{[1
]}

Sashida, Y ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Lab Med Plant Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2001年 / 24卷 / 11期

关键词：

steroidal saponin; cytotoxic activity; HL-60; cell; structure-activity relationship;

D O I：

10.1248/bpb.24.1286

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have systematically examined the cytotoxic activities of the steroidal saponins mainly isolated from the Liliaceae plants against HL-60 human promyelocytic leukemia cells and found several structure-activity relationships. Some steroidal saponins evaluated in the assay system showed considerable cytotoxic activities, which were almost as potent as that of etoposide used as a positive control. The activities were found to be sensitive to the monosaccharides constituting the sugar moieties and their sequences, as well as to the structures of the aglycons.

引用

页码：1286 / 1289

页数：4

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