A newly discovered Fc receptor that explains IgG-isotype disparities in effector responses

被引：12

作者：

Bolland, S ^{[1
]}

机构：

[1] NIAID, Immunogenet Lab, NIH, Rockville, MD 20852 USA

来源：

IMMUNITY | 2005年 / 23卷 / 01期

关键词：

D O I：

10.1016/j.immuni.2005.07.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The known IgG FcRs primarily mediate inflammation by interacting with IgG1, even though IgG2 isotypes tend to be more pathogenic. Nimmerjahn et al. (2005) have just identified a novel Fc gamma R that binds IgG2 but not IgG1, potentially explaining differences in biological activity that are seen with various IgG isotypes (Nimmerjahn et al., 2005).

引用

页码：2 / 4

页数：3

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