New features of the blocks database servers

被引:74
作者
Henikoff, JG [1 ]
Henikoff, S [1 ]
Pietrokovski, S [1 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Howard Hughes Med Inst, Seattle, WA 98109 USA
关键词
D O I
10.1093/nar/27.1.226
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Blocks are ungapped multiple sequence alignments representing conserved protein regions, and the Blocks Database consists of blocks from documented protein families. World Wide Web (http://www.blocks. fhcrc.org) and Email (blocks@blocks.fhcrc.org) servers provide tools for homology searching and for analyzing protein family relationships. New enhancements include a multiple alignment processor that extends the use of these tools to imported multiple alignments of families not present in the database and a PCR primer designer that implements a new strategy for gene isolation.
引用
收藏
页码:226 / 228
页数:3
相关论文
共 12 条
[1]   Novel developments with the PRINTS protein fingerprint database [J].
Attwood, TK ;
Beck, ME ;
Bleasby, AJ ;
Degtyarenko, K ;
Michie, AD ;
ParrySmith, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (01) :212-216
[2]   The PROSITE database, its status in 1997 [J].
Bairoch, A ;
Bucher, P ;
Hofmann, K .
NUCLEIC ACIDS RESEARCH, 1997, 25 (01) :217-221
[3]   Automated protein sequence database classification. I. Integration of compositional similarity search, local similarity search, and multiple sequence alignment [J].
Gracy, J ;
Argos, P .
BIOINFORMATICS, 1998, 14 (02) :164-173
[4]   Recent enhancements to the Blocks Database servers [J].
Henikoff, JG ;
Pietrokovski, S ;
Henikoff, S .
NUCLEIC ACIDS RESEARCH, 1997, 25 (01) :222-225
[5]  
Henikoff S, 1997, PROTEIN SCI, V6, P698
[6]   Superior performance in protein homology detection with the Blocks Database servers [J].
Henikoff, S ;
Pietrokovski, S ;
Henikoff, JG .
NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :309-312
[7]   AUTOMATED ASSEMBLY OF PROTEIN BLOCKS FOR DATABASE SEARCHING [J].
HENIKOFF, S ;
HENIKOFF, JG .
NUCLEIC ACIDS RESEARCH, 1991, 19 (23) :6565-6572
[8]  
HENIKOFF S, 1995, GENE, V163, P17
[9]   Consensus-degenerate hybrid oligonucleotide primers for amplification of distantly related sequences [J].
Rose, TM ;
Schultz, ER ;
Henikoff, JG ;
Pietrokovski, S ;
McCallum, CM ;
Henikoff, S .
NUCLEIC ACIDS RESEARCH, 1998, 26 (07) :1628-1635
[10]   SEQUENCE LOGOS - A NEW WAY TO DISPLAY CONSENSUS SEQUENCES [J].
SCHNEIDER, TD ;
STEPHENS, RM .
NUCLEIC ACIDS RESEARCH, 1990, 18 (20) :6097-6100