Mitochondrial regulation of oxygen sensing

被引：107

作者：

Bell, EL ^{[1
]}

Emerling, BM ^{[1
]}

Chandel, NS ^{[1
]}

机构：

[1] Northwestern Univ, Dept Med, Div Pulm & Crit Care Med, Chicago, IL 60601 USA

来源：

MITOCHONDRION | 2005年 / 5卷 / 05期

关键词：

mitochondria; oxygen sensing; HIF-1; angiogenesis; hypoxia;

D O I：

10.1016/j.mito.2005.06.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis by integrating the decrease in oxygen levels to increase hypoxic gene expression. How cells sense decrease in oxygen levels to elicit an increase in HIF dependent gene expression is not fully understood. In this review, we discuss the role of mitochondria as oxygen sensors regulating HIF. (c) 2005 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：322 / 332

页数：11

共 71 条

[1] Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses [J].

Adelman, DM ;

Gertsenstein, M ;

Nagy, A ;

Simon, MC ;

Maltepe, E .

GENES & DEVELOPMENT, 2000, 14 (24) :3191-3203

[2] The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia [J].

Agani, FH ;

Pichiule, P ;

Chavez, JC ;

LaManna, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (46) :35863-35867

[3] Evidence for the involvement of diacylglycerol. kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension [J].

Aragonés, J ;

Jones, DR ;

Martín, S ;

San Juan, MA ;

Alfranca, A ;

Vidal, F ;

Vara, A ;

Mérida, I ;

Landázuri, MO .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (13) :10548-10555

[4]

AW TY, 1982, J BIOL CHEM, V257, P8997

[5] A conserved family of prolyl-4-hydroxylases that modify HIF [J].

Bruick, RK ;

McKnight, SL .

SCIENCE, 2001, 294 (5545) :1337-1340

[6] Oxygen sensing in the hypoxic response pathway: regulation of the hypoxia-inducible transcription factor [J].

Bruick, RK .

GENES & DEVELOPMENT, 2003, 17 (21) :2614-2623

[7] Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation [J].

Brunelle, JK ;

Bell, EL ;

Quesada, NM ;

Vercauteren, K ;

Tiranti, V ;

Zeviani, M ;

Scarpulla, RC ;

Chandel, NS .

CELL METABOLISM, 2005, 1 (06) :409-414

[8] Oxygen sensing and molecular adaptation to hypoxia [J].

Bunn, HF ;

Poyton, RO .

PHYSIOLOGICAL REVIEWS, 1996, 76 (03) :839-885

[9] Role of HIF-1α or in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis [J].

Carmeliet, P ;

Dor, Y ;

Herbert, JM ;

Fukumura, D ;

Brusselmans, K ;

Dewerchin, M ;

Neeman, M ;

Bono, F ;

Abramovitch, R ;

Maxwell, P ;

Koch, CJ ;

Ratcliffe, P ;

Moons, L ;

Jain, RK ;

Collen, D ;

Keshet, E .

NATURE, 1998, 394 (6692) :485-490

[10] Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1α [J].

Chan, DA ;

Sutphin, PD ;

Denko, NC ;

Giaccia, AJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (42) :40112-40117

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