Going the distance: A current view of enhancer action

被引：608

作者：

Blackwood, EM

Kadonaga, JT ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Ctr Mol Genet, La Jolla, CA 92093 USA

来源：

SCIENCE | 1998年 / 281卷 / 5373期

关键词：

D O I：

10.1126/science.281.5373.60

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In eukaryotes, transcription of genes by RNA polymerase II yields messenger RNA intermediates from which protein products are synthesized. Transcriptional enhancers are discrete DNA elements that contain specific sequence motifs with which DNA-binding proteins interact and transmit molecular signals to genes. it Here, current models regarding the role of enhancers in the regulation of transcription !I by RNA polymerase II are presented.

引用

收藏

页码：60 / 63

页数：4

相关论文

共 61 条

[1] The chicken lysozyme locus as a paradigm for the complex developmental regulation of eukaryotic gene loci [J].

Bonifer, C ;

Jagle, U ;

Huber, MC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (42) :26075-26078

[2] Special HATs for special occasions: Linking histone acetylation to chromatin assembly and gene activation [J].

Brownell, JE ;

Allis, CD .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (02) :176-184

[3] MODULATION OF ENHANCER-PROMOTER INTERACTIONS BY INSULATORS IN THE DROSOPHILA EMBRYO [J].

CAI, H ;

LEVINE, V .

NATURE, 1995, 376 (6540) :533-536

[4] A 5' ELEMENT OF THE CHICKEN BETA-GLOBIN DOMAIN SERVES AS AN INSULATOR IN HUMAN ERYTHROID-CELLS AND PROTECTS AGAINST POSITION EFFECT IN DROSOPHILA [J].

CHUNG, JH ;

WHITELEY, M ;

FELSENFELD, G .

CELL, 1993, 74 (03) :505-514

[5] Genetic modification of heterochromatic association and nuclear organization in Drosophila [J].

Csink, AK ;

Henikoff, S .

NATURE, 1996, 381 (6582) :529-531

[6] Heterochromatin and gene regulation in Drosophila [J].

Elgin, SCR .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (02) :193-202

[7] Chromatin unfolds [J].

Felsenfeld, G .

CELL, 1996, 86 (01) :13-19

[8]

FREEMAN L A, 1992, Critical Reviews in Eukaryotic Gene Expression, V2, P165

[9] MODULATION OF CHROMATIN FOLDING BY HISTONE ACETYLATION [J].

GARCIARAMIREZ, M ;

ROCCHINI, C ;

AUSIO, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (30) :17923-17928

[10] Boundary and insulator elements in chromosomes [J].

Gerasimova, TI ;

Corces, VG .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (02) :185-192

← 1 2 3 4 5 6 7 →