Steroidal saponins from the aerial parts of Dracaena draco and their cytostatic activity on HL-60 cells

被引：44

作者：

Mimaki, Y ^{[1
]}

Kuroda, M ^{[1
]}

Ide, A ^{[1
]}

Kameyama, A ^{[1
]}

Yokosuka, A ^{[1
]}

Sashida, Y ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

PHYTOCHEMISTRY | 1999年 / 50卷 / 05期

关键词：

Dracaena draco; liliaceae; aerial parts; steroidal saponins; spirostanol saponins; cytostatic activity; HL-60; cells;

D O I：

10.1016/S0031-9422(98)00614-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical examination of the aerial parts of Dracaena draco has led to the isolation of a total of nine steroidal saponins, including five new ones. The structures of the new saponins were determined by spectral data and a few chemical transformations to be (23S,24S)-spirosta-5,25 (27)-diene-1 beta,3 beta,23,24-tetrol 1-O-{O-(2,3,4-tri-O-acetyl-alpha-L-rhamnopyranosyl)-alpha-L-arabinopyranosyl} 24-O-beta-D-fucopyranoside, (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta, 1-O-{O-alpha-L-rhamnopyranosyl-(l-->2)-alpha-L-arabinopyranoside}, (23S,24S)-spirosta-5,25(27)-diene-1 beta,3 beta,23,24-tetrol 1-O-{O-(4-O-acetyl-alpha-L-rhamnopyranosyl) arabinopyranoside}, (23S)-spirosta-5,25(27)-diene-1 beta,3 beta,23-triol 1-O-{O-alpha-L-rhamnopyranosyl)-(1-->2)-a-L-arabinopyranoside} and (23S)-spirosta-5,25(27)-diene-1 beta,3 beta,23-triol 1-O-{O-(4-O-acetyl-alpha-L-rhamnopyranosyl) (1-->2)-alpha-L-arabinopyranoside}. The isolated saponins were evaluated for their cytostatic activity on leukemia HL-60 cells. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：805 / 813

页数：9

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