Pentylenetetrazol-kindling modulates stimulated dopamine release in the nucleus accumbens of rats

被引：41

作者：

Becker, A ^{[1
]}

Grecksch, G ^{[1
]}

Thiemann, W ^{[1
]}

Höllt, V ^{[1
]}

机构：

[1] Otto Von Guericke Univ, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2000年 / 66卷 / 02期

关键词：

pentylenetetrazol; kindling; microdialysis; dopamine; rat;

D O I：

10.1016/S0091-3057(99)00264-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Kindling-induced activation of dopaminergic neurones in the nucleus accumbens in pentylenetetrazol (PTZ)-kindled rats was studied using microdialysis. Dopamine (DA) release after PTZ challenge was measured: (1) two weeks and (2) ten weeks after kindling completion and (3) two weeks after a kindling procedure with diazepam (DZP) treatment. In (1) a significant increase in DA concentration was found after PTZ challenge and this increase was still evident 10 weeks after kindling completion (2). Coadministration of DZP in the course of kindling development inhibited the increase in sensitivity of the accumbens dopaminergic system (3). (C) 2000 Elsevier Science Inc.

引用

页码：425 / 428

页数：4

共 14 条

[1] Diazepam - Its effects on the development of pentylenetetrazol kindling, related learning impairments, and neuronal cell loss [J].

Becker, A ;

Tiedge, A ;

Grecksch, GA .

PHARMACOLOGICAL RESEARCH, 1997, 35 (01) :27-32

[2] THE INFLUENCE OF DIAZEPAM ON LEARNING-PROCESSES IMPAIRED BY PENTYLENETETRAZOL KINDLING [J].

BECKER, A ;

GRECKSCH, G ;

MATTHIES, H .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1994, 349 (05) :492-496

[3] KINDLING AND ITS CONSEQUENCES ON LEARNING IN RATS [J].

BECKER, A ;

GRECKSCH, G ;

RUTHRICH, HL ;

POHLE, W ;

MARX, B ;

MATTHIES, H .

BEHAVIORAL AND NEURAL BIOLOGY, 1992, 57 (01) :37-43

[4] DECREASE IN THE FUNCTION OF THE GAMMA-AMINOBUTYRIC ACID-COUPLED CHLORIDE CHANNEL PRODUCED BY THE REPEATED ADMINISTRATION OF PENTYLENETETRAZOL TO RATS [J].

CORDA, MG ;

GIORGI, O ;

LONGONI, B ;

ORLANDI, M ;

BIGGIO, G .

JOURNAL OF NEUROCHEMISTRY, 1990, 55 (04) :1216-1221

[5]

Dazzi L, 1997, SYNAPSE, V26, P351

[6]

KAMPHUIS W, 1990, NEUROSCI RES COMMUN, V6, P1

[7] KINDLING - AN ANIMAL-MODEL OF COMPLEX PARTIAL EPILEPSY [J].

MCNAMARA, JO .

ANNALS OF NEUROLOGY, 1984, 16 :S72-S76

[8]

MORIMOTO K, 1992, EPILEPSY RES, P297

[9] Potentiation effects in the dentate gyrus of pentylenetetrazol-kindled rats [J].

Ruethrich, H ;

Grecksch, G ;

Becker, A ;

Krug, M .

PHYSIOLOGY & BEHAVIOR, 1996, 60 (02) :455-462

[10] RELEVANCE OF KINDLING AND RELATED PROCESSES TO HUMAN EPILEPTOGENESIS [J].

SCHMUTZ, M .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1987, 11 (04) :505-525

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