Cytogenetic and molecular genetic methods for diagnosis and treatment response in chronic granulocytic leukemia

被引：23

作者：

Dewald, GW ^{[1
]}

Juneau, AL ^{[1
]}

Schad, CR ^{[1
]}

Tefferi, A ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN, DIV HEMATOL & INTERNAL MED, ROCHESTER, MN 55905 USA

来源：

CANCER GENETICS AND CYTOGENETICS | 1997年 / 94卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(96)00292-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Today, laboratory geneticists help clinical hematologists diagnose chronic granulocytic leukemia (CGL) and monitor the response of patients undergoing treatment. The most common genetic tests for CGL include quantitative cytogenetic studies, fluorescence in situ hybridization with probes for BCR and ABL, Southern blot analysis, and reverse transcriptase polymerase chain reaction. No single genetic testing procedure fulfills all the needs of clinicians who care for patients who have CGL. Thus, it has become important to use combinations of testing methods that are both accurate and cost-effective for any given clinical situation in the diagnosis and treatment of patients with CGL. (C) Elsevier Science Inc., 1997.

引用

页码：59 / 66

页数：8

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