Heme oxygenase: Protective gene or Trojan horse

被引:217
作者
Platt, JL
Nath, KA
机构
[1] Mayo Clin & Mayo Fdn, Dept Surg, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Immunol, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Dept Pediat, Rochester, MN 55905 USA
[4] Mayo Clin & Mayo Fdn, Dept Med, Rochester, MN 55905 USA
关键词
D O I
10.1038/3947
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The induction of heme oxygenase-1 in mouse cardiac allografts that do not show accelerated arteriosclerosis suggests that this enzyme may protect against the chronic rejection of transplants (pages 1392–1396).
引用
收藏
页码:1364 / 1365
页数:2
相关论文
共 11 条
[1]  
BALLA G, 1992, J BIOL CHEM, V267, P18148
[2]   Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes [J].
Hancock, WW ;
Buelow, R ;
Sayegh, MH ;
Turka, LA .
NATURE MEDICINE, 1998, 4 (12) :1392-1396
[4]   The heme oxygenase system: A regulator of second messenger gases [J].
Maines, MD .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1997, 37 :517-554
[5]   Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide [J].
Morita, T ;
Kourembanas, S .
JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (06) :2676-2682
[6]   INDUCTION OF HEME OXYGENASE IS A RAPID, PROTECTIVE RESPONSE IN RHABDOMYOLYSIS IN THE RAT [J].
NATH, KA ;
BALLA, G ;
VERCELLOTTI, GM ;
BALLA, J ;
JACOB, HS ;
LEVITT, MD ;
ROSENBERG, ME .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (01) :267-270
[7]   TRANSPLANTATION OF DISCORDANT XENOGRAFTS - A REVIEW OF PROGRESS [J].
PLATT, JL ;
VERCELLOTTI, GM ;
DALMASSO, AP ;
MATAS, AJ ;
BOLMAN, RM ;
NAJARIAN, JS ;
BACH, FH .
IMMUNOLOGY TODAY, 1990, 11 (12) :450-456
[8]   Expression of heme oxygenase-1 can determine cardiac xenograft survival [J].
Soares, MP ;
Lin, Y ;
Anrather, J ;
Csizmadia, E ;
Takigami, K ;
Sato, K ;
Grey, ST ;
Colvin, RB ;
Choi, AM ;
Poss, KD ;
Bach, FH .
NATURE MEDICINE, 1998, 4 (09) :1073-1077
[9]   Glomerular inflammation induces resistance to tubular injury in the rat - A novel form of acquired, heme oxygenase-dependent resistance to renal injury [J].
Vogt, BA ;
Shanley, TP ;
Croatt, A ;
Alam, J ;
Johnson, KJ ;
Nath, KA .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (09) :2139-2145
[10]  
Wang LJ, 1998, AM J PATHOL, V152, P711