Effect of lecithinized-superoxide dismutase on the rat colitis model induced by dextran sulfate sodium

被引：19

作者：

Hori, Y

Hoshino, J

Yamazaki, C

Sekiguchi, T

Miyauchi, S

Mizuno, S

Horie, K

机构：

[1] Tokyo Research Institute, Seikagaku Corporation, Higashiyamato, Tokyo 207

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1997年 / 74卷 / 01期

关键词：

lecithinized-superoxide dismutase; dextran sulfate sodium; ulcerative colitis;

D O I：

10.1254/jjp.74.99

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lecithinized-superoxide dismutase (PC-SOD), which is synthesized with a lecithin derivative bound covalently to recombinant human Cu,Zn-SOD, has a longer half-life in blood and higher cell affinity than unmodified SOD. The effects of PC-SOD were evaluated using the rat ulcerative colitis model induced by 3% dextran sulfate sodium. Intravenous injection of rats with 0.5 or 1 mg/kg of PC-SOD suppressed the progression of bloody stools, the formation of erosion, and the infiltration of the colon with inflammatory cells. Furthermore, it also reduced the increase of leukocytes in blood. Thus, PC-SOD may have therapeutic potential in the treatment of ulcerative colitis.

引用

页码：99 / 103

页数：5

共 15 条

[1] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE [J].