Quantitative trait loci mapping of serum IgE in an isolated Hutterite population

被引：4

作者：

Alarcón, M

Cantor, RM

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Human Genet, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Dept Neurol, Ctr Neurobehav Genet, Los Angeles, CA USA

[4] Univ Calif Los Angeles, Neuropsychiat Res Inst, Los Angeles, CA USA

来源：

GENETIC EPIDEMIOLOGY | 2001年 / 21卷

关键词：

GENEHUNTER; genome scan; heritability; SOLAR; variance components;

D O I：

10.1002/gepi.2001.21.s1.s224

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Serum immunoglobulin E (IgE) is a quantitative trait associated with asthma. A variance components approach to the analysis of data from a subset of a founder population of Hutterites indicated that over half the variability in IgE levels may be due to genes. Two variance components methods suggest that the genetic model underlying IgE does not consist of a single major gene, but of multiple loci with more modest effects. Both approaches identified putative quantitative trait loci on chromosomes I and 21. (C) 2001 Wiley-Liss, Inc.

引用

页码：S224 / S229

页数：6

共 7 条

[1] Multipoint quantitative-trait linkage analysis in general pedigrees [J].