CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein

被引：348

作者：

Tripp, RA

Jones, LP

Haynes, LM

Zheng, HQ

Murphy, PM

Anderson, LJ

机构：

[1] Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Resp & Enter Virus Branch, Atlanta, GA USA

[2] NIAID, Host Def Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE IMMUNOLOGY | 2001年 / 2卷 / 08期

关键词：

D O I：

10.1038/90675

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokine mimicry for the G glycoprotein of respiratory syncytial virus (RSV) and show binding to CX3CRI-the specific receptor for the CX3C chemokine fractalkine-and induction of leukocyte chemotaxis. We also show that CX3CRI facilitates RSV infection of cells. Thus, G glycoprotein interaction with CX3CRI probably plays a key role in the biology of RSV infection.

引用

收藏

页码：732 / 738

页数：7

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