Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility

被引：905

作者：

Parkes, Miles

Barrett, Jeffrey C.

Prescott, Natalie J.

Tremelling, Mark

Anderson, Carl A.

Fisher, Sheila A.

Roberts, Roland G.

Nimmo, Elaine R.

Cummings, Fraser R.

Soars, Dianne

Drummond, Hazel

Lees, Charlie W.

Khawaja, Saud A.

Bagnall, Richard

Burke, Denis A.

Todhunter, Catherine E.

Ahmad, Tariq

Onnie, Clive M.

McArdle, Wendy

Strachan, David

Bethel, Graeme

Bryan, Claire

Lewis, Cathryn M.

Deloukas, Panos

Forbes, Alastair

Sanderson, Jeremy

Jewell, Derek P.

Satsangi, Jack

Mansfield, John C.

Cardon, Lon

Mathew, Christopher G.

机构：

[1] Addenbrookes Hosp, Inflammatory Bowel Dis Res Grp, Cambridge CB2 2QQ, England

[2] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

[3] Kings Coll London, Guys Hosp, Sch Med, Dept Med & Mol Genet, London SE1 9RT, England

[4] Univ Edinburgh, Western Gen Hosp, Sch Mol & Clin Med, Div Med Sci,Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland

[5] Univ Oxford, Radcliffe Infirm, Gastroenterol Unit, Oxford OX2 6HE, England

[6] Univ Newcastle Upon Tyne, Royal Victoria Infirm, Dept Gastroenterol & Hepatol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[7] Univ Bristol, ALSPAC, Bristol BS8 1TQ, Avon, England

[8] St Georges Univ London, Div Community Hlth Serv, London SW17 0RE, England

[9] Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England

[10] UCL, Hosp Trust, Inst Digest Dis, London NW1 2BU, England

[11] Guys & St Thomas NHS Fdn Trust, Dept Gastroenterol, London SE1 7EH, England

来源：

NATURE GENETICS | 2007年 / 39卷 / 07期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1038/ng2061

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A genome- wide association scan in individuals with Crohn's disease by the Wellcome Trust Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs from these and other loci for association in an independent case- control sample. We obtained replication for the autophagy- inducing IRGM gene on chromosome 5q33.1 ( replication P = 6.6 x 10(-4), combined P = 2.1 x 10(-10)) and for nine other loci, including NKX2- 3, PTPN2 and gene deserts on chromosomes 1q and 5p13.

引用

页码：830 / 832

页数：3

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