The role of local actin instability in axon formation

被引：417

作者：

Bradke, F ^{[1
]}

Dotti, CG ^{[1
]}

机构：

[1] European Mol Biol Lab, Cell Biol Programme, D-69012 Heidelberg, Germany

来源：

SCIENCE | 1999年 / 283卷 / 5409期

关键词：

D O I：

10.1126/science.283.5409.1931

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The role of localized instability of the actin network in specifying axonal fate was examined with the use of rat hippocampal neurons in culture. During normal neuronal development, actin dynamics and instability polarized to a single growth cone before axon formation. Consistently, global application of actin-depolymerizing drugs and of the Rho-signaling inactivator toxin B to nonpolarized cells produced neurons with multiple axons. Moreover, disruption of the actin network in one individual growth cone induced its neurite to become the axon. Thus, local instability of the actin network restricted to a single growth cone is a physiological signal specifying neuronal polarization.

引用

页码：1931 / 1934

页数：4

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