The t(1;3) breakpoint-spanning involved in clear cell renal cell genes LSAMP and NORE1 are carcinomas

被引：95

作者：

Chen, JD

Lui, WO

Vos, MD

Clark, GJ

Takahashi, M

Schoumans, J

Khoo, SK

Petillo, D

Lavery, T

Sugimura, J

Astuti, D

Zhang, C

Kagawa, S

Maher, ER

Larsson, C

Alberts, AS

Kanayama, HO

Teh, BT ^{[1
]}

机构：

[1] Van Andel Res Inst, Canc Genet Lab, Grand Rapids, MI 49503 USA

[2] Van Andel Res Inst, Lab Cell Struct & Signal Integrat, Grand Rapids, MI 49503 USA

[3] Karolinska Hosp, Dept Mol Med, SE-17176 Stockholm, Sweden

[4] NCI, Dept Cell & Canc Biol, NIH, Rockville, MD 20850 USA

[5] Univ Tokushima, Sch Med, Dept Urol, Tokushima 770, Japan

[6] Univ Birmingham, Sch Med, Canc Res UK Renal Mol Oncol Res Grp, Sect Med & Mol Genet, Birmingham, W Midlands, England

来源：

CANCER CELL | 2003年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1535-6108(03)00269-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

By positional cloning, we identified two breakpoint-spanning genes in a familial clear cell renal cell carcinoma (CCRCC)-associated t(1;3)(q32.1;q13.3): LSAMP and NORE1 (RASSF1 homolog). Both genes are downregulated in 9 of 9 RCC cell lines. While the NORE1A promoter predominantly presents partial methylation in 6 of the cell lines and 17/53 (32%) primary tumors, the LSAMP promoter is completely methylated in 5 of 9 cell lines and in 14/53 (26%) sporadic and 4 familial CCRCCs. Expression of LSAMP and NORE1 A proteins in CCRCC cell lines inhibited cell proliferation. These characteristics indicate that LSAMP and NORE1A may represent new candidate tumor suppressors for CCRCC.

引用

页码：405 / 413

页数：9

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