Opinion - The origin of the cancer stem cell: current controversies and new insights

被引：469

作者：

Bjerkvig, R ^{[1
]}

Tysnes, BB

Aboody, KS

Najbauer, J

Terzis, AJA

机构：

[1] Univ Bergen, Dept Biomed, N-5020 Bergen, Norway

[2] Ctr Rech Publ Sante, L-1526 Luxembourg, Luxembourg

[3] Ctr Hosp, L-1526 Luxembourg, Luxembourg

[4] City Hope Natl Med Ctr, Div Hematol Hematopoiet Cell Transplantat, Duarte, CA 91010 USA

[5] City Hope Natl Med Ctr, Div Neurosci, Duarte, CA 91010 USA

[6] Beckman Res Inst, Duarte, CA 91010 USA

来源：

NATURE REVIEWS CANCER | 2005年 / 5卷 / 11期

关键词：

D O I：

10.1038/nrc1740

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Most tumours are derived from a single cell that is transformed into a cancer-initiating cell ( cancer stem cell) that has the capacity to proliferate and form tumours in vivo. However, the origin of the cancer stem cell remains elusive. Interestingly, during development and tissue repair the fusion of genetic and cytoplasmic material between cells of different origins is an important physiological process. Such cell fusion and horizontal gene-transfer events have also been linked to several fundamental features of cancer and could be important in the development of the cancer stem cell.

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页码：899 / 904

页数：6

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