Advances in autism genetics: on the threshold of a new neurobiology

被引：1241

作者：

Abrahams, Brett S. ^{[1
,2
,3
]}

Geschwind, Daniel H. ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurogenet, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Program Neurobehav Genet, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Semel Inst Neurosci & Behav, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 05期

关键词：

D O I：

10.1038/nrg2346

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.

引用

页码：341 / 355

页数：15

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