Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication

被引：291

作者：

Bergmann, M

Garcia-Sastre, A

Carnero, E

Pehamberger, H

Wolff, K

Palese, P

Muster, T

机构：

[1] Univ Vienna, Sch Med, Dept Dermatol, A-1090 Vienna, Austria

[2] Univ Vienna, Sch Med, Dept Surg, A-1090 Vienna, Austria

[3] Mt Sinai Med Ctr, Dept Microbiol, New York, NY 10029 USA

来源：

JOURNAL OF VIROLOGY | 2000年 / 74卷 / 13期

关键词：

D O I：

10.1128/JVI.74.13.6203-6206.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The availability of an influenza virus NS1 gene knockout virus (deINS1 virus) allowed us to establish the significance of the biological relationship between the influenza virus NS1 protein and double-stranded-RNA-activated protein kinase (PKR) in the life cycle and pathogenicity of influenza virus. Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response.

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页码：6203 / 6206

页数：4

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