Pathway databases: A case study in computational symbolic theories

被引：150

作者：

Karp, PD ^{[1
]}

机构：

[1] SRI Int, Bioinformat Res Grp, Menlo Pk, CA 94025 USA

来源：

SCIENCE | 2001年 / 293卷 / 5537期

关键词：

D O I：

10.1126/science.1064621

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A pathway database (DB) is a DB that describes biochemical pathways, reactions, and enzymes. The EcoCyc pathway DB (see http://ecocyc.org) describes the metabolic, transport, and genetic-regulatory networks of Escherichia coli. EcoCyc is an example of a computational symbolic theory, which is a DB that structures a scientific theory within a formal ontology so that it is available for computational analysis. it is argued that by encoding scientific theories in symbolic form, we open new realms of analysis and understanding for theories that would otherwise be too large and complex for scientists to reason with effectively.

引用

页码：2040 / 2044

页数：5

共 16 条

[1]

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[2] The complete genome sequence of Escherichia coli K-12 [J].