Expression and evolution of the Drosophila Attacin/Diptericin gene family

被引：91

作者：

Hedengren, M

Borge, K

Hultmark, D ^{[1
]}

机构：

[1] Umea Univ, Umea Ctr Mol Pathogenesis, S-90187 Umea, Sweden

[2] Univ Stockholm, Wenner Gren Inst, S-10691 Stockholm, Sweden

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 279卷 / 02期

关键词：

antibacterial peptides; immunity; Drosophila melanogaster;

D O I：

10.1006/bbrc.2000.3988

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the genes for three new glycine-rich antimicrobial peptides in Drosophila, two attacins (AttC and AttD) and one diptericin (DptB). Their structures support the proposal that these glycine-rich antimicrobial peptides evolved from a common ancestor and are probably also related to proline-rich peptides such as drosocin. AttC is similar to the nearby AttA and AttB genes. AttD is more divergent and located on a different chromosome. intriguingly, AttD may encode an intracellular attacin. DptB is linked in tandem to the closely related Diptericin. However, the DptB gene product contains a furin-like cleavage site and may be processed in an attacin-like fashion. All attacin and diptericin genes are induced after bacterial challenge. This induction is reduced in imd mutants, and unexpectedly also in Tl- mutants. The 18w mutation particularly affects the induction of AttC, which may be a useful marker for 18w signaling. (C) 2000 Academic Press.

引用

页码：574 / 581

页数：8

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